Allergy Conditions

Asthma Medicines and How they Work

Written by Dr Sam Risenga, Dr Bhadrish Vallabh, Dr Des Cohen, Dr Archie

Mhlambi

Endorsed by ALLSA and SACAWG

 

INTRODUCTION

Although asthma medicines are essential, it is important to remember

that they are not the only part of asthma treatment (see booklet

Allergy, and Asthma).

 

Asthma medicines act by preventing or controlling asthma, so people

with asthma must take these medicines every day, even when they

are well – just like people with high blood pressure or epilepsy

or diabetes have to take their medicine every day to stay well.

 

There are two types of drugs used in the treatment of asthma – preventers

and relievers. There is no connection between the effects of preventer

and reliever drugs. They do separate things.

 

Preventers

Preventers build up a protective shield in the linings of the breathing

tubes (called airways or bronchi) and thereby stop or reduce swelling,

mucus build-up and muscle tightening in your air-ways caused by triggers

They will not work unless used regularly, so must be taken every day

even when you are well They do not bring any relief from symptoms (see

Relievers below) They take about 14 days to build up the protective

shield. You will therefore not see an immediate effect but after 1-2

weeks they will make a big difference in the amount of asthma symptoms

you have There are two families of preventers: Steroids – inhaled and

oral Cromolyn Preventers available in South Africa are listed below.

Drug names beginning with a capital letter are their trade names (the

ones you will see in shops), and the ones beginning with a smaller letter

refer to their chemical names (used by chemists and doctors).

 

Trade name Chemical Name
Steroids: Inhaled Flixotide, fluticasone
Inflammide, Pulmicort budesonide
Aerobec, Becotide, Becloforte, Clenil, Ventzone, Viarox beclomethasone
Steroids: Oral – Syrup Prelone prednisolone
Celestone, Celestamine betamethasone
Steroids: Oral – Tablets Be-tabs Prednisone, Meticorten, Panafcort prednisone
Lenisolone, Meticorlone, Predeltin prednisolone
Cromolyns Lomudal sodium cromoglycate
Tilade nedocromil sodium

 

Steroids

Steroids

are a wide range of chemicals made both by the body and artificially

One group of steroids, the corticosteroids, are used to treat asthma

Corticosteroids are different from the anabolic steroids taken by some

athletes. Anabolic steroids are not used to treat asthma They are the

strongest inhaled preventers They are used for moderate and severe asthma

Your doctor should advice you whether to decrease or increase the dose

you are taking, or stop these medicines where possible. Do not adjust

doses without your doctor’s advice When inhaled they are usually used

twice daily

 

They can be taken in 3 ways:

Inhaled (breathing them into the lungs), swallowed, either tablets or

syrup injected for acute, severe asthma

 

Inhaled steroids

Inhalation is the preferred because: The drug goes straight to the site

where it acts, the lungs The smallest dose possible is used which results

in fewer side-effects Side-effects are uncommon, but can be hoarse voice

or oral thrush, both of which can be prevented my mouth rising with

water after inhalation growth suppression (only when taken in high doses)

Side-effects are reduced if a spacer is used, so if you are using a

high dose, it is advisable to us a spacer Children can take up to 400

micrograms per day (mcg/day) and teenagers up to 1500 mcg/day without

fear of any side-effects Oral

 

Oral steroids

Some people have asthma which is troublesome most of the time even when

taking medicines regularly and avoiding triggers. They may need long-term

oral steroids all the time When experiencing at attack of asthma, the

asthmatic might need a short-term oral steroids (course of 7-10 days)

to treat the attack

 

Short-term (course) oral steroids

Are available as a syrup or as tablets Usually given to relieve an acute

attack of asthma They are used when inhaled steroids fail to control

symptoms adequately Usually given for 7-10 days Many patients will keep

such a course at home which call be used when their asthma worsens,

as shown by increasing symptoms, especially at night or with exercise,

or by a fall in their peak now rate When taking oral steroids some people

notice and increase in appetite and slight weight gain. Long-term oral

steroids

 

A small group of asthmatics need to take a low dose oral steroids on

a long term basis because their symptoms continue to be quite significant

and their asthma uncontrolled, despite high doses of inhaled steroids

This is becoming less common with the improvements in inhaled steroid

therapy Long-term oval steroids can have adverse effects of growth retardation

in children weight gain high blood pressure osteoporosis or thinning

of the bones tendency to diabetes cataracts To try to avoid or minimise

these side-effects, doctors try to use the smallest dose that will control

the asthma If you are taking long-term oral steroids you may have to

take extra during illnesses such as a bad cold, an asthma attack or

an operation When reducing the dose, your asthma must be carefully watched

by your doctor to ensure that it doesn’t worsen

 

Injecting steroids

Steroids can be injected only by a doctor or nurse They are usually

only used to treat acute, severe asthma when the patient cannot swallow

the oval steroids

 

Cromolyns
  • Used in people with moderate asthma
  • Has mild side-effects of irritation of the throat, coughing,hoarseness, dry mouth, nausea and vomiting
  • Your child should continue his treatment even if feelingwell
  • Symptoms may not be relieved initially and 2 weeks of continuoustreatment may be needed for maximal effect to develop
  • Children seem to respond better than adults
  • This medicine may be taken as powder inhaler (spincaps),nebuliser solution or by aerosol
  • Tilade is not licensed for use in children under six

 

Relievers
  • One of the major causes of cough, wheeze or tight chestthat asthmatics experience is bronchospasm which is tightening

    of the muscle around the airways called bronchospasm (see what

    is asthma?)

  • Bronchospasm is relieved by medicines called bronchodilatorsor relievers which help open the airways and make breathing

    easier

  • Relievers produce nearly instant relief and for this reasonare used as “first aid” treatment for asthma symptoms or attacks.

    Always carry them with you

  • Relievers have no effect on the swelling in the airwaysor the build up of mucous
  • Relievers are used only when the person with asthma hassymptoms. If you need to use a reliever more than a 3x a week

    you should also be on a preventer

  • Some asthmatic need to use relievers before exercise eventhough their asthma is well controlled by preventers
  • Shakiness and a fast heart beat can occur when relievermedicines are first used, or when larger than normal doses are

    used. These effects disappear once the medicines have been used

    for a few weeks

  • Reliever medicines are in two forms. inhalants or oral preparations

Bronchodilators

Inhaled bronchodilators

  • Inhaled medicines are preferred as they go directly andrapidly to the airways allowing smaller doses than oral medicines

    to be used

  • Inhaler or spacer devices allow us to use asthma pumps inchildren of all ages
  • There are two types of inhaled bronchodilators
    • short-acting beta-agents
    • long-acting beta-agents
  • Short-acting beta-agents are the reliever medicines alreadydescribed
  • Long-acting beta-agents have a duration of action for 12hours and are used for troublesome night-time and activity (exercise)

    induced symptoms. They are always used with preventer medicines

Oral bronchodilators

  • These are available as syrups, tablets or capsules
  • They take longer than inhaled bronchodilators work as theyhave to go the ‘long way round’ before they act on the lungs
  • There are two types of oral bronchodilators
    • beta-agents
    • theophyllines

Oral beta-agents

  • Because higher strengths have to be used than inhaled beta-agents,side effects such as tremor, headache, sleeplessness and simply

    a nervous feeling often occur

Theophyllines

  • There are two groups of theophyllines:
    • short-acting – duration of action 4-6 hours
    • long-acting – duration of action about 12 hours
  • Rectally administered theophyllines can be potentiallydangerous and are not recommended
  • Over the last few years these medicines have been prescribedless frequently, mainly because they commonly produce side-effects

    such as

    • stomach upset, indigestion, heartburn, loss of appetite,nausea and vomiting,
    • headache, sleeplessness, excited or nervous feeling,
    • palpitations
  • Long-acting theophyllines are started in low dosesand are used once or twice a day
  • Your doctor will send you for a blood test to measure thelevel of theophylline in the blood to determine the

    correct dosage

  • Note that some other drugs e.g. antibiotics such as erythromycinmight interfere with the action of theophyllines so be sure

    to check with your doctor before taking any new medicines

Trade name Chemical Name
Short Acting Bronchodilators

a) Beta Agents

Abbutamol, Breatheze, Salbulin, Venteze, Ventolin, Viavent salbutamol
Ipradol hexoprenaline
Berotec, Fensol fenoterol
Bricanyl terbutaline
b) Theophyllines Alcophyllin, Biophyllin, Choledyl, Nuelin, Solphyllin, Theostat,

Vernthol

Long-acting bronchodilators
a) Beta-agents
Foradil formoterol
Serevent salmeterol
b) Theophyllines Chronophyllin, Euphyllin Retard, Microphyllin, Neulin SA

Tabs, Theo-Dur, Theoylus, Uni-Dur, Uniphyl

Other medicines
  • Homeopathic medicines are not recommended for asthma. Ifyou do wish to use these please do not stop your child’s usual

    asthma medicines as prescribed by your doctor

  • Antihistamines can be used for other allergic conditionssuch as hay fever but are not considered to be standard asthma

    medicines.

  • Antibiotics are rarely necessary as viral infections areby far the most common triggers of asthma attacks. The decision

    to use or not to use them will rest with the attending doctor.

  • Cough mixtures are of no benefit in asthma management asthe cough is most often a sign of poor asthma control needing

    reliever medicines

  • Tranquillisers are dangerous as they may suppress the breathingprocess especially in severe asthma attacks
  • Desensitisation is not recommended as asthma treatment asit is not effective and can be potentially dangerous
  • lonisers are ineffective

 

5 key points to remember

Preventers

  • Inhaled steroids are the most effective preventer medicines
  • Inhaling steroids are safe at doses use most commonly
  • Spacers reduce the risk of side effects
  • Tablets may need to be used in a short course for an asthmaattack
  • Steroids used in asthma are not anabolic steroids used byathletes

 

Relievers
  • Relievers are a measure of how well your asthma is beingcontrolled. If you need relievers regularly it means you are

    not getting enough preventer medicine

  • Short-acting beta-agents should only be used when asthmasymptoms appear or before exercise
  • Inhaled short-acting beta-agents act very quickly to relievesymptoms
  • Long-acting beta-agents are used for troublesome night-timeand exercise induced symptoms
  • Theophyllines are uncommonly used because of side-effects