Allergy Conditions
Asthma Medicines and How they Work
Written by Dr Sam Risenga, Dr Bhadrish Vallabh, Dr Des Cohen, Dr Archie
Mhlambi
Endorsed by ALLSA and SACAWG
INTRODUCTION
Although asthma medicines are essential, it is important to remember
that they are not the only part of asthma treatment (see booklet
Allergy, and Asthma).
Asthma medicines act by preventing or controlling asthma, so people
with asthma must take these medicines every day, even when they
are well – just like people with high blood pressure or epilepsy
or diabetes have to take their medicine every day to stay well.
There are two types of drugs used in the treatment of asthma – preventers
and relievers. There is no connection between the effects of preventer
and reliever drugs. They do separate things.
Preventers
Preventers build up a protective shield in the linings of the breathing
tubes (called airways or bronchi) and thereby stop or reduce swelling,
mucus build-up and muscle tightening in your air-ways caused by triggers
They will not work unless used regularly, so must be taken every day
even when you are well They do not bring any relief from symptoms (see
Relievers below) They take about 14 days to build up the protective
shield. You will therefore not see an immediate effect but after 1-2
weeks they will make a big difference in the amount of asthma symptoms
you have There are two families of preventers: Steroids – inhaled and
oral Cromolyn Preventers available in South Africa are listed below.
Drug names beginning with a capital letter are their trade names (the
ones you will see in shops), and the ones beginning with a smaller letter
refer to their chemical names (used by chemists and doctors).
Trade name | Chemical Name | |
---|---|---|
Steroids: Inhaled | Flixotide, | fluticasone |
Inflammide, Pulmicort | budesonide | |
Aerobec, Becotide, Becloforte, Clenil, Ventzone, Viarox | beclomethasone | |
Steroids: Oral – Syrup | Prelone | prednisolone |
Celestone, Celestamine | betamethasone | |
Steroids: Oral – Tablets | Be-tabs Prednisone, Meticorten, Panafcort | prednisone |
Lenisolone, Meticorlone, Predeltin | prednisolone | |
Cromolyns | Lomudal | sodium cromoglycate |
Tilade | nedocromil sodium |
Steroids
Steroids
are a wide range of chemicals made both by the body and artificially
One group of steroids, the corticosteroids, are used to treat asthma
Corticosteroids are different from the anabolic steroids taken by some
athletes. Anabolic steroids are not used to treat asthma They are the
strongest inhaled preventers They are used for moderate and severe asthma
Your doctor should advice you whether to decrease or increase the dose
you are taking, or stop these medicines where possible. Do not adjust
doses without your doctor’s advice When inhaled they are usually used
twice daily
They can be taken in 3 ways:
Inhaled (breathing them into the lungs), swallowed, either tablets or
syrup injected for acute, severe asthma
Inhaled steroids
Inhalation is the preferred because: The drug goes straight to the site
where it acts, the lungs The smallest dose possible is used which results
in fewer side-effects Side-effects are uncommon, but can be hoarse voice
or oral thrush, both of which can be prevented my mouth rising with
water after inhalation growth suppression (only when taken in high doses)
Side-effects are reduced if a spacer is used, so if you are using a
high dose, it is advisable to us a spacer Children can take up to 400
micrograms per day (mcg/day) and teenagers up to 1500 mcg/day without
fear of any side-effects Oral
Oral steroids
Some people have asthma which is troublesome most of the time even when
taking medicines regularly and avoiding triggers. They may need long-term
oral steroids all the time When experiencing at attack of asthma, the
asthmatic might need a short-term oral steroids (course of 7-10 days)
to treat the attack
Short-term (course) oral steroids
Are available as a syrup or as tablets Usually given to relieve an acute
attack of asthma They are used when inhaled steroids fail to control
symptoms adequately Usually given for 7-10 days Many patients will keep
such a course at home which call be used when their asthma worsens,
as shown by increasing symptoms, especially at night or with exercise,
or by a fall in their peak now rate When taking oral steroids some people
notice and increase in appetite and slight weight gain. Long-term oral
steroids
A small group of asthmatics need to take a low dose oral steroids on
a long term basis because their symptoms continue to be quite significant
and their asthma uncontrolled, despite high doses of inhaled steroids
This is becoming less common with the improvements in inhaled steroid
therapy Long-term oval steroids can have adverse effects of growth retardation
in children weight gain high blood pressure osteoporosis or thinning
of the bones tendency to diabetes cataracts To try to avoid or minimise
these side-effects, doctors try to use the smallest dose that will control
the asthma If you are taking long-term oral steroids you may have to
take extra during illnesses such as a bad cold, an asthma attack or
an operation When reducing the dose, your asthma must be carefully watched
by your doctor to ensure that it doesn’t worsen
Injecting steroids
Steroids can be injected only by a doctor or nurse They are usually
only used to treat acute, severe asthma when the patient cannot swallow
the oval steroids
Cromolyns
- Used in people with moderate asthma
- Has mild side-effects of irritation of the throat, coughing,hoarseness, dry mouth, nausea and vomiting
- Your child should continue his treatment even if feelingwell
- Symptoms may not be relieved initially and 2 weeks of continuoustreatment may be needed for maximal effect to develop
- Children seem to respond better than adults
- This medicine may be taken as powder inhaler (spincaps),nebuliser solution or by aerosol
- Tilade is not licensed for use in children under six
Relievers
- One of the major causes of cough, wheeze or tight chestthat asthmatics experience is bronchospasm which is tightening
of the muscle around the airways called bronchospasm (see what
is asthma?)
- Bronchospasm is relieved by medicines called bronchodilatorsor relievers which help open the airways and make breathing
easier
- Relievers produce nearly instant relief and for this reasonare used as “first aid” treatment for asthma symptoms or attacks.
Always carry them with you
- Relievers have no effect on the swelling in the airwaysor the build up of mucous
- Relievers are used only when the person with asthma hassymptoms. If you need to use a reliever more than a 3x a week
you should also be on a preventer
- Some asthmatic need to use relievers before exercise eventhough their asthma is well controlled by preventers
- Shakiness and a fast heart beat can occur when relievermedicines are first used, or when larger than normal doses are
used. These effects disappear once the medicines have been used
for a few weeks
- Reliever medicines are in two forms. inhalants or oral preparations
Bronchodilators
Inhaled bronchodilators
- Inhaled medicines are preferred as they go directly andrapidly to the airways allowing smaller doses than oral medicines
to be used
- Inhaler or spacer devices allow us to use asthma pumps inchildren of all ages
- There are two types of inhaled bronchodilators
- short-acting beta-agents
- long-acting beta-agents
- Short-acting beta-agents are the reliever medicines alreadydescribed
- Long-acting beta-agents have a duration of action for 12hours and are used for troublesome night-time and activity (exercise)
induced symptoms. They are always used with preventer medicines
Oral bronchodilators
- These are available as syrups, tablets or capsules
- They take longer than inhaled bronchodilators work as theyhave to go the ‘long way round’ before they act on the lungs
- There are two types of oral bronchodilators
- beta-agents
- theophyllines
Oral beta-agents
- Because higher strengths have to be used than inhaled beta-agents,side effects such as tremor, headache, sleeplessness and simply
a nervous feeling often occur
Theophyllines
- There are two groups of theophyllines:
- short-acting – duration of action 4-6 hours
- long-acting – duration of action about 12 hours
- Rectally administered theophyllines can be potentiallydangerous and are not recommended
- Over the last few years these medicines have been prescribedless frequently, mainly because they commonly produce side-effects
such as
- stomach upset, indigestion, heartburn, loss of appetite,nausea and vomiting,
- headache, sleeplessness, excited or nervous feeling,
- palpitations
- Long-acting theophyllines are started in low dosesand are used once or twice a day
- Your doctor will send you for a blood test to measure thelevel of theophylline in the blood to determine the
correct dosage
- Note that some other drugs e.g. antibiotics such as erythromycinmight interfere with the action of theophyllines so be sure
to check with your doctor before taking any new medicines
Trade name | Chemical Name | |
Short Acting Bronchodilators
a) Beta Agents |
Abbutamol, Breatheze, Salbulin, Venteze, Ventolin, Viavent | salbutamol |
---|---|---|
Ipradol | hexoprenaline | |
Berotec, Fensol | fenoterol | |
Bricanyl | terbutaline | |
b) Theophyllines | Alcophyllin, Biophyllin, Choledyl, Nuelin, Solphyllin, Theostat,
Vernthol |
|
Long-acting bronchodilators a) Beta-agents |
Foradil | formoterol |
Serevent | salmeterol | |
b) Theophyllines | Chronophyllin, Euphyllin Retard, Microphyllin, Neulin SA
Tabs, Theo-Dur, Theoylus, Uni-Dur, Uniphyl |
Other medicines
- Homeopathic medicines are not recommended for asthma. Ifyou do wish to use these please do not stop your child’s usual
asthma medicines as prescribed by your doctor
- Antihistamines can be used for other allergic conditionssuch as hay fever but are not considered to be standard asthma
medicines.
- Antibiotics are rarely necessary as viral infections areby far the most common triggers of asthma attacks. The decision
to use or not to use them will rest with the attending doctor.
- Cough mixtures are of no benefit in asthma management asthe cough is most often a sign of poor asthma control needing
reliever medicines
- Tranquillisers are dangerous as they may suppress the breathingprocess especially in severe asthma attacks
- Desensitisation is not recommended as asthma treatment asit is not effective and can be potentially dangerous
- lonisers are ineffective
5 key points to remember
Preventers
- Inhaled steroids are the most effective preventer medicines
- Inhaling steroids are safe at doses use most commonly
- Spacers reduce the risk of side effects
- Tablets may need to be used in a short course for an asthmaattack
- Steroids used in asthma are not anabolic steroids used byathletes
Relievers
- Relievers are a measure of how well your asthma is beingcontrolled. If you need relievers regularly it means you are
not getting enough preventer medicine
- Short-acting beta-agents should only be used when asthmasymptoms appear or before exercise
- Inhaled short-acting beta-agents act very quickly to relievesymptoms
- Long-acting beta-agents are used for troublesome night-timeand exercise induced symptoms
- Theophyllines are uncommonly used because of side-effects